נָשַׁ֣מּוּ מְסִלּ֔וֹת שָׁבַ֖ת עֹבֵ֣ר אֹ֑רַח הֵפֵ֤ר בְּרִית֙ מָאַ֣ס עָרִ֔ים לֹ֥א חָשַׁ֖ב אֱנֽוֹשׁ׃
The highways lie waste, The wayfaring man ceaseth; He hath broken the covenant, He hath despised the cities, He regardeth not man.
Rashi on Isaiah
he has abrogated the treaty The enemy has abrogated the treaty he made with Israel.
Ibn Ezra on Isaiah
The highways lie waste. For the king of Assyria will not be faithful to his treaties with other nations.
Rashi on Isaiah
despised cities He despised in his eyes; no enemy considers any man.