אֲרָ֣ם מִקֶּ֗דֶם וּפְלִשְׁתִּים֙ מֵֽאָח֔וֹר וַיֹּאכְל֥וּ אֶת־יִשְׂרָאֵ֖ל בְּכָל־פֶּ֑ה בְּכָל־זֹאת֙ לֹא־שָׁ֣ב אַפּ֔וֹ וְע֖וֹד יָד֥וֹ נְטוּיָֽה׃
The Arameans on the east, and the Philistines on the west; and they devour Israel with open mouth. For all this His anger is not turned away, but His hand is stretched out still.
Rashi on Isaiah
Aram from the east Aram harmed them from the east in the days of Jehoahaz and Joash, and the Philistines harmed them from the west, for the Philistines are west of them.
Ibn Ezra on Isaiah
The Syrians, etc. The Syrians in the east of Israel will join Assyria to do evil to Israel.
Rashi on Isaiah
despite all this...and His hand is still outstretched until He brings Sennacherib upon them. Alternatively: Aram from the east and the Philistines from the west were wreaking destruction in Judah in the days of Ahaz, as is explained in Chronicles (II 28:18), and over Israel and Judah as well, Isaiah was lamenting because of these misfortunes.