רָאִ֨יתִי אֶת־אֲדֹנָ֜י נִצָּ֣ב עַֽל־הַמִּזְבֵּ֗חַ וַיֹּאמֶר֩ הַ֨ךְ הַכַּפְתּ֜וֹר וְיִרְעֲשׁ֣וּ הַסִּפִּ֗ים וּבְצַ֙עַם֙ בְּרֹ֣אשׁ כֻּלָּ֔ם וְאַחֲרִיתָ֖ם בַּחֶ֣רֶב אֶהֱרֹ֑ג לֹֽא־יָנ֤וּס לָהֶם֙ נָ֔ס וְלֹֽא־יִמָּלֵ֥ט לָהֶ֖ם פָּלִֽיט׃
I saw the Lord standing beside the altar; and He said: Smite the capitals, that the posts may shake; And break them in pieces on the head of all of them; And I will slay the residue of them with the sword; There shall not one of them flee away, And there shall not one of them escape.
Akeidat Yitzchak
That concept was taught to Jacob in the dream via the vision of the ladder. Another way of expressing the lesson is this: Only after mastery of the lessons of ma-aseh bereshit, the workings of the physical universe, can one hope to gain insights into ma-asseh merkavah, the workings of celestial relationships.