וְהֵ֛מָּה מָר֥וּ וְעִצְּב֖וּ אֶת־ר֣וּחַ קָדְשׁ֑וֹ וַיֵּהָפֵ֥ךְ לָהֶ֛ם לְאוֹיֵ֖ב ה֥וּא נִלְחַם־בָּֽם׃
But they rebelled, and grieved His holy spirit; therefore He was turned to be their enemy, Himself fought against them.
Read kabbalistic (mystical) interpretation of Isaiah 63:10: and classical mystical sources.