וּבַגּוֹיִ֤ם הָהֵם֙ לֹ֣א תַרְגִּ֔יעַ וְלֹא־יִהְיֶ֥ה מָנ֖וֹחַ לְכַף־רַגְלֶ֑ךָ וְנָתַן֩ יְהוָ֨ה לְךָ֥ שָׁם֙ לֵ֣ב רַגָּ֔ז וְכִלְי֥וֹן עֵינַ֖יִם וְדַֽאֲב֥וֹן נָֽפֶשׁ׃
And among these nations shalt thou have no repose, and there shall be no rest for the sole of thy foot; but the LORD shall give thee there a trembling heart, and failing of eyes, and languishing of soul.
Orchot Tzadikim
Anger is a bad quality and just as scurvy is a disease of the body so is anger a disease of the soul. And our sages have said : "He who loses his temper is exposed to all the torments of hell" (Nedarim 22a) as it is said : "Therefore, remove vexation from thy heart, and put away evil from thy flesh" (Eccl. 11:10), and by "evil" they mean Gehenna, as it is said : "The Lord hath made everything for His own purpose, Yes, even the wicked for the day of evil" (Prov. 16:4). And not only this but an angry man is afflicted with piles as it is said : "The Lord will give you there an anguished heart and eyes that pine, and a despondent spirit" (Deut. 28:65). What ill is it that dims the eyes and pains the soul— Surely you will say "Piles".