Quoting Commentary for I Samuel 5:6

וַתִּכְבַּ֧ד יַד־יְהוָ֛ה אֶל־הָאַשְׁדּוֹדִ֖ים וַיְשִׁמֵּ֑ם וַיַּ֤ךְ אֹתָם֙ בעפלים [בַּטְּחֹרִ֔ים] אֶת־אַשְׁדּ֖וֹד וְאֶת־גְּבוּלֶֽיהָ׃

But the hand of the LORD was heavy upon them of Ashdod, and He destroyed them, and smote them with emerods, even Ashdod and the borders thereof.

Rashi

And He smote His adversaries from the rear Plagues of the rear with hemorrhoids, which is a disgrace of perpetual ridicule for them.
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