יָמִ֤יקוּ ׀ וִידַבְּר֣וּ בְרָ֣ע עֹ֑שֶׁק מִמָּר֥וֹם יְדַבֵּֽרוּ׃
Они издеваются, и в злобе совершают притеснения; они говорят так, как будто их не было на высоте.
Radak
"Let them melt away." This verse is a prayer or wish for the wicked to be dissolved or destroyed. The commentary states that the term "מנחי העי"ן" (literally "the guidance of the eye") is not found in Scripture, but rather in the words of our sages. Additionally, the term "מק בשרו" (literally "his flesh") refers to the act of multiplying or duplicating, which can be found in his work and others.
Rashi
they speak about the Most High e.g. Pharaoh, Sennacherib, and Nebuchadnezzar. [Pharaoh said] (Exod. 5:2): “Who is the Lord that I should obey Him?” [Sennacherib said] (Isa. 36:20), “Who are they among all the gods of the lands...?” [Nebuchadnezzar said] (Isa. 14:14), “I will ascend above the heights of the clouds.” That is the meaning of: “They have set their mouth against Heaven.”