Kabbalah zu Schemot 3:15

Dor (“Generation”). Yesod and Tiferet; or Binah and Malkhut. This is [what is meant by the expression] to all generations (Exod. 3:15).

We understand from this article that one who damaged his Brit needs to suffer harsh afflictions that are close to death, until the meat on which is written the sin disintegrates. Specifically one who emits semen in vain, who deserves death, must accept upon himself suffering close to death. The reason is because the damages relates to the actual name of Yud-Kei-Vav-Kei, which includes the [248] Positive Precepts and the [365] Negative Precepts. “This is my name for ever, and this is my memorial to all generations” (Shemot 3:15). Sh’mi (eng. ‘my name’) plus Yud-Hei is 365 in numerical value, and Zichri (eng. ‘my memorial’) plus Vav-Hei equals 248. Thus he damages all of the Positive and Negative Precepts, and he needs afflictions like these for all of them specifically.