Comentario citado sobre Génesis 25:21

It is important to appreciate that the power of prayer is such that it can bring about changes in the laws of nature, save people from mortal danger, and bring about cancellation of evil decrees by G’d. We know that it can effect changes in the laws of nature from Yitzchak whose prayer in the presence of Rivkah brought about the new-found ability of Rivkah to conceive (Genesis 25,21). She had previously been barren, and our sages explain that this was so as G’d wanted to encourage Yitzchak to pray to Him to reverse this situation. (compare Shir Hashirim Rabbah 2,31). Our sages explained to us that the barrenness of our matriarchs was due only to the absence of the prayers of either themselves or their husbands.
Proof that prayer can save one from mortal danger is found in Psalms 107,23: “the ones who descend to the sea in ships.” We know that from when Jonah prayed inside the fish, surely a mortal danger if ever there was such. Not only this, but David continues in that psalm describing how the mariners in time of a storm pray to G’d Who saves them from these dangers. As a result of their prayers G’d silences these turbulent waters (verse 29).
Proof that prayer is able on occasion to reverse evil decrees by G’d is found in Isaiah 38,8 where G’d tells King Chizkiyah that his prayer has been granted that he will enjoy a 15 year extension of his lifespan after the prophet had told him in the name of G’d to make his last will and testament as he would not recover from his sickness. (Compare Berachot 10 on what the king told the prophet.) The Talmud tells us not to despair even if the sword is poised to fall on one’s neck, that G’d is still able to help. They quote Job 13,15 to prove their point. Incidentally, our sages there reveal that the power of prayer exceeds the power of prophecy.
In this connection we must remember that in the period between Moses and the men of the Great Assembly (over 900 years later) prayer was not formalized as it is nowadays. Every person formulated his prayers in his own words in accordance with his knowledge and ability. The men of the Great Assembly organised the formula which serves until this day as the principal prayer commonly known a the Shmone Esreh, (“18,” according to the number of benedictions which it contains). The main reason the men of the Great Assembly formulated this prayer was to ensure that everyone would learn it by heart and be familiar with it. This is why the language of that prayer is very plain and simple.
This would prevent people from becoming confused and making errors. The sages wanted the prayers of both fools and wise men to be identical so that the fools would not feel at a disadvantage.
These benedictions were composed with the utmost care and with regard to such formulas having proved successful. The introductory benediction, known as אבות introduces the petitioner as a descendant of the patriarchs and as such entitled to a hearing. It is followed by a benediction known as גבורות, a declaration of our awareness of G’d’s mighty deeds. The third benediction is called קדושה, a prayer in which we extol G’d’s Holiness. These three benedictions are followed by a string of בקשות, requests (12 in all) which are arranged both in terms of our spiritual needs, our physical needs, our national needs and our individual needs. The final three benedictions consist of עבודה, a prayer asking for the restoration of the Temple and the sacrificial service in the Temple, followed by a benediction known as הודאה, thanksgiving. This is followed by the blessing by the priests, the prayer for peace, without which all the other blessings are short-lived.
If you will examine the letters in the tetragrammaton י-ה-ו-ה you will find that if the letters of that name are spelled in a different sequence you have a total of 12 variations, known as צירופים, permutations. An example of these variations is that starting with the first letter י you could follow it with either a ו followed by two letters ה, or by the letter ה twice followed by the letter ו. The three basic letters in the tetragrammaton, the letters י-ה-ו lend themselves to six permutations, i.e. יהו,יוה,הוי,היו,ויה,והי giving you a total of 6 such צירופים. The tetragrammaton, having four basic letters, doubles the number of permutations possible so that you wind up with basically 12 צירופים. [Some authorities speak about 24. Ed]. The number 12 corresponds to the numerical value of the word זה in the verse זה שמי לעולם, “this is My name forever” (Exodus 3,15). The three first permutations, i.e. the ones using the letter י at the beginning, correspond to the first three of the benedictions representing אבות, גבורות, קדושה. The final three צירופים in that series correspond to the last three benedictions עבודה, הודאה, ברכת כהנים. The 6 permutations in the middle correspond to six of the 12 central requests, i.e. אתה חונן, השיבנו, סלח לנו, גאולה, רפואה, פרנסה. The other six benedictions do not have a specific permutation of the tetragrammaton assigned to them and one can perceive them as being used interchangeably. The reason that the 19th benediction, the one added by later sages as a request to ward off the potential damage caused to Jews and Judaism by its defectors and maligners cannot be assigned any of these permutations of the tetragrammaton is that this benediction is addressed in the first instance to the attribute of Justice, not the tetragrammaton as we want that attribute to neutralize these anti Jewish forces.
This nineteenth benediction and its significance has already been alluded to in Psalms 29 where after mentioning the tetragrammaton 18 times, David adds the words ואל הכבוד הרעים, in verse 3, a reference to the attribute of Justice. The only reason David changes the attribute he addresses there after having referred to the tetragrammaton 18 times is that he hints that this attribute ought to be poised, ready to strike these virulent anti-Semites unless they retract.
Another reason that David introduces an additional attribute of G’d in that psalm is that he conveys the message that not only our external enemies but our internal enemies, the evil urge, should be taken care of by the attribute of Justice. We encourage the attribute of Justice, so to speak, to vent its anger on our internal enemies.

and He accepted their prayers וְנַעְתּוֹר, similar to if וַיֵּעָתֵר לוֹ accepted his prayer (Gen. 25:21).

Since we just had a statement about a pitchfork, the Talmud cites a completely unrelated statement concerning the pitchfork. In Genesis 25:21 Isaac “entreats” the Lord on behalf of his barren wife. The word for entreat is ויעתר which has the same root as the word for pitchfork, עתר. R. Elazar says that prayer is compared to a pitchfork because prayer has the ability to overturn God’s harsh judgments.

They cried out there was no one to deliver them. The words of verse are not written in order [the proper order should be] "They will cry out to Adonoy but He will not answer them and no one will deliver them"²⁷The two words ואין מושיע need to be removed from their position at the beginning of the verse and placed instead at the end of the verse as its last two words. as [we find], "Man will turn to his Maker",²⁸Yeshayohu 17:7. as if to say "turn".²⁹i.e., ישעה means “turn to.” Menachem connected [the word יִשְׁעֶה] with [the verse,] "Adonoy listened to Hevel",³⁰Bereishis 4:4. and he [Menachem] interpreted it as "listening." This word can be used to denote both the listener and the listened to as [we find], "Yitzchok implored Adonoy… and Adonoy listened to him."³¹Bereishis 25:21. So too here "They will implore [God] and they will not be saved"³²In our verse. is a case where the word יִשְׁעוּ is refering to the one praying and "Adonoy listened…"³³By Hevel’s offering. is a case where the word is refering to the [Holy] One being prayed to.