פירוש על בראשית 3:18

וקוץ ודרדר תצמיח לך THORNS ALSO AND THISTLES SHALL IT BRING FORTH TO THEE— תצמיח has for subject the earth; when you sow it with various kinds of grain, it shall bring forth thorns and thistles — artichokes and cardoon — which are fit for food only after special preparation (Genesis Rabbah 20:10).

וקוץ ודרדר, in lieu of the seed you plant beginning to sprout, the earth will produce thorns and thistles, which are not only useless, but which harm the plants your seed will produce, so that you will have to engage in eradicating them

And thorns: There will be times when the toil will not benefit you. However you will not die of hunger, but rather, "you will eat, etc."