מדרש על איוב 5:21

(Gen. 27, 2) The voice is the voice of Jacob, but the hands are the hands of Esau. The [first] voice alludes to the voice of lamentation caused by Hadrian, who had at Alexandria in Egypt massacred twice the number of Jews that had come forth out of Egypt. The voice is the voice of Jacob, refers to a similar lamentation occasioned by Vespasian, who put to death four hundred myriads in the city of Byther, or, as some say, four thousand myriads. The hands are the hands of Esau, that there is no victorious battle which is not fought by the descendants of Esau; and this is what is meant by the passage (Job 5, 21) Against the scourge of the tongue shall thou be hidden; i.e., from a strifesome tongue shalt thou keep aloof."