Tafsiran Kejadian 4:16: Rashi, Chizkuni, Ramban & Kli Yakar

ויצא קין AND CAIN WENT AWAY — He went away in pretended humility as though he would deceive the Most High (Genesis Rabbah 22:13).

ויצא קין מלפני ה, “Kayin left the Presence of Hashem;” this formula also appears in Esther 8,15, where Mordechai is described as leaving the Presence of the King. The verse informs us that on account of his exile, Kayin was given a new lease on life, and he accepted G-d’s judgment. He was eventually killed inadvertently after seven generations.

AND CAIN WENT OUT FROM THE PRESENCE OF THE ETERNAL. The sense thereof is that he never stood before Him any more, as he meant when he said, and from Thy face shall I be hid,⁴⁴¹Verse 14. [as explained above].
And he dwelt in the land of Nod. The sense thereof is that Cain did not traverse the entire world, but he dwelt in that land, perpetually wandering therein and not resting at all in any one place thereof, and so it was forever called “the land of Nod (wandering)” after him.

בארץ נוד IN THE LAND OF NOD — In the land where all exiles wander about.