וְהַקְּטֹ֙רֶת֙ אֲשֶׁ֣ר תַּעֲשֶׂ֔ה בְּמַ֨תְכֻּנְתָּ֔הּ לֹ֥א תַעֲשׂ֖וּ לָכֶ֑ם קֹ֛דֶשׁ תִּהְיֶ֥ה לְךָ֖ לַיהוָֽה׃
Mengenai ukupan yang akan kaubuat itu, janganlah kamu membuat ukupan menurut takaran ramuannya untuk dirimu sendiri. Ukupan itu harus menjadi kudus bagimu, khusus bagi Yang Mahakekal.
Or HaChaim
והקטרת אשר תעשה, "And the incense which you are to make, etc." According to Keritut 6 the words: "you shall make," mean that Moses was to separate an amount needed for the daily incense offerings from the total on the day it would be used. This means that if an individual would compound an amount of incense of even half the daily portion offered on the altar, [the daily portion was divided into a half to be offered in the morning and the other half to be offered close to evening. Ed.] such an individual would be guilty of the most severe karet penalty; he would be cut off from his people (for all times).
Rashbam
'ושחקת ממנה וגו, the reason some had to be rubbed into fine particles was that on Yom Kippur the incense was to be of fine particles as we know from Leviticus 16,12 קטורת סמים דקה.
Siftei Chakhamim
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‘קדש תהיה לך לה IT SHALL BE UNTO THEE HOLINESS FOR THE LORD — This means that you must not make it except in honour of My Name.