וְהֵ֛מָּה מָר֥וּ וְעִצְּב֖וּ אֶת־ר֣וּחַ קָדְשׁ֑וֹ וַיֵּהָפֵ֥ךְ לָהֶ֛ם לְאוֹיֵ֖ב ה֥וּא נִלְחַם־בָּֽם׃
Ma si ribellarono e addolorarono il suo spirito santo; perciò fu trasformato in loro nemico, lui stesso combatté contro di loro.
Targum Jonathan on Isaiah
But they rebelled against the word of His holy prophets, and blasphemed, and His WORD became their enemy, and He waged war against them.