אוּלַ֥י יֵ֛שׁ חֲמִשִּׁ֥ים צַדִּיקִ֖ם בְּת֣וֹךְ הָעִ֑יר הַאַ֤ף תִּסְפֶּה֙ וְלֹא־תִשָּׂ֣א לַמָּק֔וֹם לְמַ֛עַן חֲמִשִּׁ֥ים הַצַּדִּיקִ֖ם אֲשֶׁ֥ר בְּקִרְבָּֽהּ׃
그 성중에 의인 오십이 있을지라도 주께서 그 곳을 멸하시고 그 오십 의인을 위하여 용서치 아니하시리이까
Akeidat Yitzchak
Man's beginnings, i.e. the potential he is born with, call it genes or whatever, are a gift of G-d, something beyond his control. Similarly, G-d’s help is required for man to be able to bring to fruition all the potential he has been equipped with at birth. However, on the way toward the attainment of his potential, man must employ all his willpower, endurance, diligence etc. though all of these by themselves do not guarantee that he will meet with success.