Musar do Izajasza 44:13

We had raised the question in the introduction to Parshat Bereshit, why the Talmud in Chagigah 2 did not quote the commandment of פרו ורבו in Genesis when it wanted to tell us about the severity of neglecting to fulfill the commandment of procreation, and chose the line from Isaiah about G–d not having created the universe in order for it to remain תהו, in an elementary state. We can now understand this when we consider that the message the Talmud wanted to convey was that someone who fails to heed that commandment is as if he arrested the whole process of creation and its purpose by allowing the universe to remain static, in the state of Tohu, its very beginning.