Commentary for Lamentations 3:41

Let us uplift our hearts together with our hands. When we lift up our hands to heaven let us also lift up our hearts with them to return, to bring back our hearts before the Omnipresent, Blessed is He. Another explanation: “With our hands.” אֶל כַּפָּיִם means] to the clouds, to heaven, as [Scripture] states, “There is a cloud as small as a man’s palm, rising.”³¹I Melochim 18:44. And similarly, “Over the clouds He covers the rain.”³²Iyov 36:32. But the Midrash of our Rabbis [states], “Let us uplift our hearts” sincerely to the Holy One, Blessed Is He, like a person who washes his hands to clean them, casts from his hands all contamination, for “he who confesses and abandons will obtain mercy,” but he who confesses but does not abandon [his sins] is like one who [is ritually impure who] immerses himself while holding a[n impure] creeping animal in his hand.³³Until he casts it away he will not become ritually pure. See Rashi in Maseches Ta’anis 16a.