Rashi on Genesis
זאת הפעם THIS NOW — This teaches that Adam endeavoured to find a companion among all cattle and beasts, but found no satisfaction except in Eve (Yevamot 63a).
Rashbam on Genesis
זאת הפעם עצם מעצמי, “only this time will man’s wife be made of his own bone and flesh; in the future things will be reversed, a male will come forth from a female, not as this time.”